Saturday, 27 June 2020

These 3 Incurable Diseases Will Have A Cure In 2020s


Incurable diseases


Some diseases which are being cured today were once major threats to lives around the world. However, with some series of research, studies, and investments, the medical solutions to some were discovered. Despite such advancement in the medical field, it is important to note that there are still lots of incurable diseases in the world today.

This post will reveal some incurable diseases that are likely to have a cure by the end of 2020s.


Diabetes

Diabetes still remains a genuine threat to lives around the world. The major cause of diabetes is an increase in blood sugar-level and fluctuations in insulin-levels. There are two types of diabetes, type 1 and type 2. Even though type 2 is as deadly as type 1, it can be managed by exercise, diet-control and insulin injections. Type 1 is more severe and deadly. Below we’ll discuss Pancreatic Islets transplantation which, in recent times, has shown promising results during its human experimental phase to treat diabetes.

Incurable diseases

What is Pancreatic Islets?

Pancreatic Islets are a group of cells in our pancreas that help produce insulin. The idea of Islet transplantation is old, and it was not approved by the FDA due to procedural complications and lack of research. One such complication was the cell self-destruction due to lack of oxygen, and second, rejection of Islet cells by the body.

Dr. Thakor, Assistant Professor, Department of Radiology, recently published a white paper addressing the oxygen depletion issue in newly transplanted Islet cells. In short, he was successful in making a collagen-based bio gel that could be safely transplanted along with the Islet cells and provide enough oxygen to new cells until the Islet cells are able to start producing their own oxygen reservoir. Thakor research is remarkable in a sense that Islet transplantation can be adopted sooner than later. The issue of body rejection of Islet cells can be resolved by immunosuppressant drugs.

Although the above treatments are in their initial phases, there is some light at the end of the tunnel for possible treatments for deadly diseases such as Diabetes mellitus.

Good news is, FDA is expected to approve Islet transplantation later this year.


Gaucher disease

For more than 40 years, scientists are trying to cure various types of genetic diseases and one such disease is Gaucher disease or GD. A person with this disease suffers from blood disorders which ultimately can lead to death due to overcrowding of normal cells with fatty substances.

Scientists, so far, have been successful in treating GD type 1 through ERT (enzyme replacement therapy), but type 2 and 3 remain incurable.

Although ERT is a breakthrough in treating GD type 1, lifelong intravenous infusions every 2 weeks is a big hurdle for both the patient and the doctor. All is not that bad, researchers have developed an oral treatment that works by slowing down production of glucocerebroside, the main enzyme responsible for blood anomalies. The substrate reduction therapy (SRT) was approved by the FDA in 2003 for patients with mild-to-moderate Gaucher disease. Thanks to modern medicine a more potent oral SRT medication is available which can replace IV infusions. The oral medication has to be taken twice a day to slow the production of glucocerebroside.

Unfortunately, SRT and ERT, are not effective in controlling GD type 2 and 3. To control type 2 and 3 scientists are experimenting on a next generation SRT which could cross the blood-brain barrier and, if successful, will not only cure GD but would also open doors for effective treatments for more advanced diseases such as Parkinson’s and Dementia.

Gene therapy is another approach scientists are exploring to treat various types of genetic orders, including GD.

AAV (Adeno-associated viruses) is a new type of gene therapy in which deactivated/modified viruses will be used to administer gene therapy at the cellular level. These viruses will not have the ability to infect, instead would have the ability to precisely replace the defected DNA strand with the healthy one.

Another promising contender in treating GD and other genetic disorders is the CRISPR-CAS system. This new gene-editing technology can permanently correct genetic irregularities. After successful clinical trials and decades of research, this technology is ready to revolutionize the field of biomedicine.


AIDS

Incurable disease

AIDS is probably the most dreaded amongst other sexually transmitted diseases around the world. In a continent such as Africa, it kills thousands of people every year. AIDS (Acquired Immunodeficiency Syndrome) is the latter stage of HIV (Human Immune Virus). Once it gets to such a stage, victims become prone to various pathogens.

Even though the above virus may seem quite frightening, scientists have already succeeded in controlling the disease with CCR5-Δ32 deletion treatment.

To multiply, HIV needs a co-receptor, CCR5, if that is controlled, the disease can be controlled, and the researchers did that and were able to eradicate HIV-related diseases like myeloid leukemia (AML) in some patients.

Although HIV can take a different route if CCR5 is not available, mainly blocking CCR5 can do the job as alternative routes for HIV spread depends on a lot of other factors.

Timothy Ray Brown is officially the first person to be cleared of HIV. Brown was studying in Berlin when he first contracted the disease. He was treated with stem cell transplantation from CCR5-Δ32 homozygous donor. He is now fully cured of HIV.

Another patient, Adam Castillejo, also received a similar treatment plus some low intensity radiation. Treatment was successful, and Castillejo is also fully cured of HIV as of 2020.

The ongoing CCR5-blocking treatment seems promising, and scientists hope that HIV will be fully cured in the 2020s.


Conclusion

Summarizing all above, there’s no doubt in my mind that we’re going to see some remarkable breakthroughs in different types of diseases and disorders in the 2020s.


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These 3 Incurable Diseases Will Have A Cure In 2020s

Some diseases which are being cured today were once major threats to lives around the world. However, with some series of research, studies,...